转化生长因子βⅡ型受体在乳腺癌中的表达

Expression of the Type Ⅱ Transforming Growth Factorβ- Receptor in Breast Carcinoma

目的研究转化生长因子βⅡ型受体（ＴＧＦ－βＲⅡ）表达与乳腺癌生物学行为和预后的关系。方法应用免疫组织化学ＳＰ方法检测１０２例乳腺癌手术标本中ＴＧＦ－βＲⅡ的表达情况。结果乳腺癌原发灶ＴＧＦ－βＲⅡ表达阳性率为２５．４９％，其中无区域淋巴结转移者阳性率为４４．７４％，有转移者阳性率为１４．０６％（Ｐ＜０．０１）。ＴＧＦ－βＲⅡ表达水平与乳腺癌大小和ＴＮＭ分期进展呈负相关（Ｐ＜０．０１，Ｐ＜０．０１）。ＴＧＦ－βＲⅡ阳性者术后３年、５年生存率分别为９６．１５％，６８．７８％，而阴性者为５７．８９％，４１．２２％。二组患者术后３年、５年生存率差别均有显著性（Ｐ＜０．０５）。结论乳腺癌组织中由于ＴＧＦ－βＲⅡ减少而逃逸ＴＧＦ－β的生长抑制作用，加速恶性细胞的增殖、浸润和转移。故检测乳腺癌组织中ＴＧＦ－βＲⅡ表达状况，有助于进一步了解乳腺癌生物学行为和对患者预后的判断。

Objective\ To study the relations between the type Ⅱ transforming growth factorbeta receptor (TGFβRⅡ) expression and biological behavior or prognosis in breast carcinoma.\ Methods\ The expression of TGFβRⅡ was examined immunohistochemically in resected breast carcinoma,using polyclonal antibody.\ Results\ Of 102 patients tested,25.49%(26 cases) showed positive staining of TGFβRⅡ in the primary lesions,while others(74.41%) were negative.\ Tumors without regional nodal metastasis showed significantly higher positive staining rate(44.74%,17/38) than those with nodal involvement(14.06%,9/64;P< 0.01 ).\ Inverse relationships were found between TGFβRⅡ expression and tumor size or the progression of TNM stage(P<0.01).\ Expression of TGFβRⅡ was positively associated with longer postoperative survival(P<0.05).\ Conclusions\ The data indicated that reduction in TGFβRⅡ resulted in escape from growth inhibitory effect of TGFβ and malignant cells increased proliferation,invasion and metastasis.\ The expression of TGFβRⅡ may be a useful tool for prognosis evaluation of human breast carcinoma.