转化生长因子βⅡ型受体在胰腺癌中的表达及其意义

Expression of the Type Ⅱ Transforming Growth Factorβ Receptor in Pancreatic Carcinoma and its Significance

目的研究转化生长因子βⅡ型受体（ＴＧＦ－βＲⅡ）在胰腺癌组织中的表达情况，探讨其临床病理意义。方法应用免疫组化ＳＰ法结合微波抗原修复法检测５０例胰腺癌和３８例非胰癌组织（胰腺良性病变及正常组织）中ＴＧＦ－βＲⅡ表达情况。结果ＴＧＦ－βＲⅡ在胰腺癌组织中表达阳性率为９６％（４８／５０），在非胰腺癌组织中表达阳性率为１００％（３８／３８）。两者在统计学上差别无意义，但在表达的强度上存在差异。ＴＧＦ－βＲⅡ在胰腺癌组织中等强度以上表达率为７０％（３５／５０），明显低于非胰腺癌组织１００％（３８／３８）（Ｐ＜０．０１）。ＴＧＦ－βＲⅡ在胰腺癌中的表达强度随着组织分化程度的降低而降低（Ｐ＜０．０１）。结论ＴＧＦ－βＲⅡ低表达可能与胰腺癌的发生有关。ＴＧＦ－βＲⅡ的表达强度与胰腺癌的组织分化密切相关。

Objective\ To study the expression of the type Ⅱ transforming growth factorbeta receptor(TGFβRⅡ) in pancreatic carcinoma and its significance.\ Methods\ By using immunohistochemical methods,expression of TGFβRⅡ was studied in 50 cases of pancreatic carcinoma,38 cases of pancreatic nonneoplastic tissue(benign pancreatic diseases and normal pancreatic tissue).\ Results\ The positive rate of TGFβRⅡ in pancreatic carcinoma was 96%(48/50) and in pancreatic nonneoplastic tissue was 100%(38/38).\ But the rate of TGFβRⅡ expression with moderate intensity or more(～) in pancreatic carcinoma(70%,35/50) was lower than in pancreatic nonneoplastic tissue(100%,38/38)(P<0.01).\ The expression intensity of TGFβRⅡ in pancreatic carcinoma decreased with decreasing grades of differentiation (P<0.01).\ Conclusion\ Loss of TGFβRⅡ expression may be involved in pancreatic carcinoma.\ The expression intensity of TGFβRⅡ was closely correlated to differentiation of pancreatic carcinoma.