摘要
目的研究胃癌DNA微小卫星体不稳定性(MIN)及其与胃癌生物学行为的关系。方法采用放射性同位素PCR为基础的重复差错(RER)测定方法,对106例系列胃癌进行研究。结果RER阳性在膨胀性生长方式胃癌中的表达明显高于在浸润性生长方式胃癌中的表达(P<0.01),而RER阳性与胃癌组织学类型,pTNM分期以及年龄和性别无明显关系(P>0.05)。结论提示MIN在相当一部分胃癌,尤其在被公认为愈后良好的膨胀性生长方式胃癌的发生、发展过程中起着非常重要的作用。
Objective\ To study the relationship between microsatellite instability(MIN) and biological behaviour of gastric cancer(GC).\ Metheds\ MIN was examined in a series of 106 cases of GC,using radioactive PCRbased technique of RER analysis \ Results\ The frequency of MIN was significantly higher in expanding type of GC compared to the infiltrative type of GC(P<0 01).\ No significant association with histologic type,pTNM stage,age and sex was found in our study(P>0 05).\ Conclusion\ These findings indicated that MIN might be an important contributor to the development and progress of a significant number of GC,especially in expanding type of GC which traditionally has a better prognosis.
出处
《福建医科大学学报》
1998年第1期62-65,共4页
Journal of Fujian Medical University
关键词
微小卫星体
不稳定性
胃癌
生物学行为
microsatellite instabiliby\ \ stomach neoplasms\ \ bioligical behaviour