微小卫星体不稳定性与胃癌生物学行为的关系

Relationship between Microsatellite Instability and Biological Behaviour of Gastric Cancer

目的研究胃癌ＤＮＡ微小卫星体不稳定性（ＭＩＮ）及其与胃癌生物学行为的关系。方法采用放射性同位素ＰＣＲ为基础的重复差错（ＲＥＲ）测定方法，对１０６例系列胃癌进行研究。结果ＲＥＲ阳性在膨胀性生长方式胃癌中的表达明显高于在浸润性生长方式胃癌中的表达（Ｐ＜０．０１），而ＲＥＲ阳性与胃癌组织学类型，ｐＴＮＭ分期以及年龄和性别无明显关系（Ｐ＞０．０５）。结论提示ＭＩＮ在相当一部分胃癌，尤其在被公认为愈后良好的膨胀性生长方式胃癌的发生、发展过程中起着非常重要的作用。

Objective\ To study the relationship between microsatellite instability(MIN) and biological behaviour of gastric cancer(GC).\ Metheds\ MIN was examined in a series of 106 cases of GC,using radioactive PCRbased technique of RER analysis \ Results\ The frequency of MIN was significantly higher in expanding type of GC compared to the infiltrative type of GC(P<0 01).\ No significant association with histologic type,pTNM stage,age and sex was found in our study(P>0 05).\ Conclusion\ These findings indicated that MIN might be an important contributor to the development and progress of a significant number of GC,especially in expanding type of GC which traditionally has a better prognosis.