摘要
患者男，28岁。因躯干色素减退斑8年就诊。皮疹为色素减退性斑片，大小一不，境界不清，表面无鳞屑，色减斑片在躯干近中线处融合。真菌学直接镜检阴性。Wood灯检查显示皮损区域毛囊性红色荧光。组织病理学仅提示基底层见色素减少，皮肤电镜提示皮损处黑素小体数目较临近正常处皮肤减少，且以Ⅰ～Ⅲ期为主，周围正常皮肤处黑素小体以Ⅳ期为主。根据患者临床表现、Wood灯检查及组织病理、皮肤电镜结果，确诊为进行性斑状色素减少症。窄谱UVB治疗有效。
A 28-year-old male patient presented with hypopigmented patches on the trunk and upper limbs for 8 years. The lesions were characterized by multiple, variously sized, ill-defined, non-scaly, hypopigmented patches that were confluent around the midline trunk. Potassium-hydroxide test of skin scrapings was negative. Wood＇s lamp examination of the lesions revealed red follicular fluorescence. Histopathology exhibited a decrease in pigmentation in the basal layer. Under an electron microscope, fewer melanosomes were observed in lesions compared with adjuvant normal skin; melanosomes at stage Ⅰ -Ⅲ predominated in lesions, but stage Ⅳ melanosomes in adjuvant normal skin. The case was diagnosed as progressive macular hypomelanosis according to the clinical feature, results of Wood＇s lamp test, histopathological and electron microscopic examination. The lesions responded well to narrow-band UVB phototherapy.
出处
《国际皮肤性病学杂志》
2009年第5期276-277,共2页
International Journal of Dermatology and Venereology
关键词
进行性斑状色素减少症
诊断
治疗
Progressive macular hypomelanosis
Diagnosis
Therapy
