奥马珠单抗治疗过敏性疾病

Omalizumab in the treatment of allergic diseases

奥马珠单抗是重组化、人源化抗IgE单克隆抗体，可选择性与高亲和力IgE受体结合，降低血浆中游离的IgE水平，从而抑制由IgE引起的一系列生物学效应。同时还对嗜碱粒细胞、肥大细胞、B细胞等具有调节作用。临床上主要用于治疗哮喘、荨麻疹、湿疹等过敏性疾病，有着良好的安全性和耐受性。相信该药的使用将会为过敏性疾病的治疗带来新的希望。

Omalizumab is a recombinant humanized monoclonal antibody against IgE, which can lower the level of free IgE in plasma and inhibit a series of biological effects caused by IgE by selectively binding to high-affinity IgE receptors. At the same time, it can regulate the behavior of basophilic granulocytes, mast cells and B cells. Clinically, it is mainly used in the treatment of asthma, urticaria, eczema ＇and other allergic diseases, and has shown a favorable safety and tolerability profile. It is expected to bring new hope for the treatment of allergic diseases.