药物诱导性红斑狼疮

Drug-induced lupus erythematosus

药物诱导性红斑狼疮是一种药物诱导的自身免疫病，目前已知的相关药物超过80种。临床表现为关节痛、肌痛、发热和血清学异常，如ANA、抗组蛋白抗体阳性等，停止使用这些药物后临床症状可迅速缓解或消退，但血清学异常可能持续较长时间。对于药物诱导性红斑狼疮的研究不仅有助于揭示SLE的发病机制，也有助于临床合理防治。

Drugqnduced lupus erythematosus （DILE） is an autoimmune disease induced by different drugs. At present, more than 80 drugs have been shown to be associated with this disease. It is characterized by arthmlgia, myalgia, fever and serological abnormality （such as antinuclear antibody and antihistone antibodies）. After discontinuation of associated drugs, clinical symptoms can be improved promptly, but laboratory abnormality may persist for a long time. To study about DILE is not only helpful to reveal the pathogenesis of SLE but also beneficial to the reasonable prevention and treatment of SLE.