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毛乳头细胞生物学特性和功能研究进展 被引量：4

Biological characteristics and functions of dermal papilla cells
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摘要 毛乳头细胞在毛囊形态发生、生长周期调控及维持毛发生长发育中起重要作用，并具有在体内外条件下重建毛囊的功能。同时，毛乳头细胞具有明显的成体干细胞特性。毛乳头细胞生物学特性和功能是毛囊细胞生物学研究的重要内容，可为脱发性疾病的诊治、含有毛囊等附件的全功能组织工程皮肤的构建及干细胞组织工程研究提供理论基础。 Dermal papilla cells （DPC） play an essential role in embryonic formation of hair follicles, regulation of hair growth cycle and maintenance of hair growth. It has been proved that cultured DPC have the ability to induce hair follicle regeneration in vivo and in vitro. At the same time, DPC have obvious properties of adult stem cells. Biological characteristics and functions of DPC are a focus in hair follicle cell biology research, and to study into them will provide theoretical basis for the diagnosis and treatment of hair loss, construction of tissue engineering skin with hair follicles and stem cell-based tissue engineering research.
作者 刘官智 伍津津
机构地区 四川省自贡市第四人民医院皮肤科 第三军医大学大坪医院野战外科研究所皮肤科
出处 《国际皮肤性病学杂志》 2009年第5期324-326,共3页 International Journal of Dermatology and Venereology
关键词 毛囊 毛乳头细胞 干细胞 生物学 Hair follicle Dermal papilla cells Stem cells Biology
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献17

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同被引文献65

  • 1马兰花,李发成.自动毛发移植系统结合毛发移植器修复毛发缺损[J].中国美容医学,2005,14(2):171-172. 被引量：3
  • 2FLOTTE T J.Transverse sectioning of the scalp(Headington technique)in the 19th century[J].J Cutan Pathol,2008,35(1):82-85.
  • 3BOUHANNA P.Multifactorial classification of male and female androgenetic aiopecia[J].Dermatol Stag,2000,26(6):555-561.
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  • 5HWANG S T,KIM H Y,LEE S J,et al.Recipient-site influence in hair transplantation:a confirmative study[J].Dermatol Surg,2009,35(6):1011-1014.
  • 6Matsumoto T, Shiina H, Kawano H, et al.Androgen receptor functions in male and female physiology[J].J Steroid Biochem Mol Biol, 2008, 109 ( 3 ) : 236-241.
  • 7Sawant N, Chikhalkar S, Mehta V, et al.Androgenetic alopecia: quality-of-life and associated lifestyle patterns[J].Int J Trichology, 2010, 2 (2):81-85.
  • 8Hillmer A M, Flaquer A, Hanneken S, et al.Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26[J].Am J Hum Genet, 2008, 82 ( 3 ) : 737-743.
  • 9Inui S, Itami S.Molecular basis of androgenetic alopecia: from androgen to paracrine mediators through dermal papilla[J].J Dermatol Sci, 2011, 61 (1): 1-6.
  • 10Kitagawa T, Matsuda K, fnui S, et al.Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells[J].Clin Endocrinol Metab, 2009, 94 ( 4 ) : 1288-1294.

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国际皮肤性病学杂志
2009年 第5期

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