CCND1基因870位点多态性同肿瘤遗传易感性关系的Meta分析

Polymorphism of CCND1 at 870 loci on genetic susceptibility to cancer:a meta-analysis

目的:综合评价细胞周期蛋白D1(Cy-clin D1)基因CCND1的G870A多态性与肿瘤遗传易感性的关系。方法:以"CCND1、CyclinD1、Bcl-1、polymorphism、cancer、细胞周期蛋白(素)D1、多态性和肿瘤"为关键词,检索Med-line、EMBASE、Springerlink、Highwire、CBM、CNKI、维普和万方等中英文数据库,获得1991-01-2008-09有关CCND1基因G870A多态性同肿瘤易感性关系的研究结果。对所获文献进行质量评价、筛选和异质性检验,要求所纳入文献均为非相关的病例对照研究,均以OR值为效应指标,基因型在对照群体中的分布均符合Hardy-Weinberg遗传平衡定律。利用RevMan4.2软件进行Meta分析。结果:共纳入26篇研究文献,累计病例7444例,对照11909例。A/G和A/A等位基因同G/G纯合子相比,OR值分别为1.10(95%CI:1.00～1.22)和1.34(95%CI:1.16～1.55),对应的P值分别为0.06和<0.0001。结论:CCND1G870A能够增加携带者患肿瘤的发病风险,A/A基因型是其患肿瘤的一个遗传易感因素。

OBJECTIVE： To determine whether the single nucleotide polymorphism （SNP） of CCND1 at G870A loci contributes to genetic susceptibility to cancer, through summarizing the results of published works in this field by a meta-analysis. METHODS： MEDLINE, EMBASE, CBM disc, CNKI, and some other databases were searched for literatures published from January 1991 to September 2008. Articles were identified using the Medical Subject Headings term ＂CCND1, Cyclin D1, Bcl-1, polymorphism, cancer＂. Case control studies involving unrelated subjects and genotype frequencies in control group consistent with Hardy-Weinberg equilibrium were included. The software Review Manager （Version 4.2） was used for meta analysis. RESULTS： Twenty-six studies including 7 444 patients and 11 909 controls met the selection criteria. The combined OR of susceptibility to cancer with A/G and A/A compared to G/G were 1.10（95%CI：1.00--1.22） and 1.34（95% CI：1. 16--1.55）, and their responding P values were 0.06 and d0. 0001, respectively. CONCLUSION： Although bias cannot be excluded, the findings suggest that the A allele of the CCND1 G870A polymorphism is correlated with the presence of cancer and A/A homozygote is potentially one of the genetic risk factors for cancer.