膀胱移行细胞癌组织Notch-1和Jagged-1蛋白表达临床意义的探讨

Expressions and clinical significance of Notch-1 and Jagged-1 in bladder transitional cell carcinoma tissues

目的:探讨Notch-1及其配体Jagged-1在膀胱移行细胞癌组织中的表达及临床意义。方法:采用免疫组化SP法检测Notch-1和Jag-ged-1在52例膀胱移行细胞癌组织和10例正常膀胱组织中的表达,并结合临床资料进行分析。结果:52例膀胱癌组织中Notch-1和Jag-ged-1蛋白的阳性表达率分别为76.9%(40/52)和75.0%(39/52)。10例正常膀胱组织中Notch-1阳性表达率为40.0%(4/10),Jagged-1阳性表达率为50.0%(5/10)。随着膀胱癌病理分级和临床分期的增高,Notch-1和Jagged-1蛋白的阳性表达率均增高,P<0.05。复发组Notch-1和Jagged-1蛋白的阳性表达率均高于未复发组,差异有统计学意义,P<0.05。Notch-1和Jagged-1的表达强度之间呈明显正相关,r=0.316,χ2=5.200,P=0.013。结论:Notch-1及其配体Jagged-1可能是判断膀胱癌生物学行为的重要指标。

OBJECTIVE： To investigate the expressions of Notch-1 and Jaggedl in bladder transitional cell carcinoma tissues and their clinical significance. METHODS：The expressions of Notch-1 and Jagged-1 in 52 specimens of bladder transitional cell carcinoma and 10 specimens of normal bladder tissues were detected by SP of immunohistoehemistry. The results were analyzed in relation to the clinical data. RESULTS： The positive rates of Notch-1 and Jagged-1 in bladder carcinoma were 76.9% （40/52） and 75.0O/oo （39/52）, respectively. The positive expression rates of Notch-1 and Jagged-1 were 40.0% （4/10） and 50.0% （5/10） respectively in the 10 nomal bladder tissues. The abnormal expressions of Notch-1 and Jagged-1 were related to the tumor grade, clinical stage and recurrence,P〈0.05. Meanwhile, the correlation between Notch-1 expression and Jagged-1 expression was statistically significant （r= 0. 316, χ^2 = 5. 200, P=0. 013）. CONCLUSION： Notch 1 and Jagged-1 may be important prognostic indicators and potentially useful for assessing the biological behavior of bladder transitional cell carcinoma.