生物活性肽抗肿瘤作用的研究进展

Progress of research on anti-cancer mechanism of bioactive peptides

目的:总结国内外对生物活性肽抗肿瘤机制的研究现状。方法:以"生物活性肽、多肽、肿瘤和细胞凋亡"等为关键词,应用CNKI中文数据库和PubMed英文数据库,检索1998-2008年相关活性肽抗肿瘤方面的文献,共收集142篇关于活性肽方面的文章,纳入标准:1)合成多肽抗肿瘤作用机制的研究;2)生物活性肽抗肿瘤作用机制的研究;3)抗肿瘤药物作用机制研究。根据纳入标准,选取40篇具有代表性的与本研究有关的文献进行分析。结果:生物活性肽可通过抑制肿瘤新生血管生成、调控蛋白降解、干扰肿瘤细胞DNA合成、调控细胞周期及诱导细胞凋亡等多种机制发挥抗肿瘤作用。结论:生物活性肽具有很好的抑制肿瘤生长作用,且毒副反应小,它的开发利用和进一步深入研究具有重要意义。

OBJECTIVE： To summarize the situation of the research on the anti-cancer mechanism of bioactive peptides. METHODS.. The databases such as CNKI and PubMed were used to search documents about bioactive peptides from 1998--2008, with ＂bioactive peptide, polypeptide, tumor and cell apoptosis＂ as the key words. A total of 142 articles were collected. Standards of getting in.. l）about the mechanism of antitumor effect of synthetic peptides; 2）about the mechanism of antitumor effect of bioactive peptides; 3）about the mechanism of antitumor drugs. According to the above standards, a total of 40 representative focus literature were selected into analysis. RESULTS：Bioactive peptides can exert an antitumor effect by various mechanisms, including anti-angiogenesis, protein degradation regulation, interference of DNA synthesis in tumor cells, cell cycle regulation or inducing cell apoptosis and so on. CONCLUSIONS： Bioactive peptide has the function of retarding tumor growth with little poisonous side effect. The further studies and the exploitation would be of great importance.