不同孔径介孔分子筛MCM–41的合成及载药释药性能(英文)

SYNTHESIS AND DRUG LOADING/RELEASE PERFORMANCE OF MESOPOROUS MOLECULAR SIEVE MCM–41 WITH TUNABLE PORE SIZES

通过添加辅助剂1,3,5-三甲基苯合成不同孔径的介孔分子筛(mesoporous molecular sieves,MCM-41)。将利尿性氢氯噻嗪引入到MCM-41的孔道内,采用低温N2吸附-脱附、X射线衍射、Fourier红外光谱仪、热重分析等表征MCM-41材料,并测定了氢氯噻嗪在模拟体液中的释放率。结果表明:合成的MCM-41具有均一的介孔结构,孔径在4.0～5.6nm,氢氯噻嗪在MCM-41-B(具有最大的孔径)中的释放速率较快,10h释放了79%,其他材料的需20h,而且氢氯噻嗪的释放速率随着孔径的增加而减小,表明已制得了氢氯噻嗪的缓释体系,并且可以通过控制孔径来调节氢氯噻嗪的释放速率。

Mesoporous molecular sieves MCM–41 with different pore sizes were synthesized by adding certain amounts of 1,3,5-trimethyl benzene,and diuretic hydrochlorothiazide was introduced into the pores of MCM–41 materials. The MCM–41 materi-als were characterized by the low-temperature nitrogen absorption–desorption,X-ray diffraction,Fourier transform infrared spectros-copy,and thermogravimetry analysis,etc. The release rate of hydrochlorothiazide from MCM–41 materials in simulated body fluid was examined by the ultraviolet spectrophotometry. Results show that the synthesized MCM-41 has a uniform mesoporous structure and the average pore size ranges from 4.0nm to 5.6nm. Hydrochlorothiazide release from the MCM-41-B is fast. In MCM-41-B with the biggest pore size, it takes 10 h to reach 79% release, whereas the others take 20 h. Hydrochlorothiazide release rates are reduced with the decrease of pore size. Results show that the sustained release system of hydrochlorothiazide/MCM-41 is prepared and the hydrochlorothiazide release rate can be adjusted by controlling the pore size.