促凋亡基因bax在上皮性卵巢肿瘤中的表达及意义

Expression and significance of proapoptosis gene bax in epithelial ovarian tumour

目的：探讨促细胞凋亡基因ｂａｘ在上皮性卵巢肿瘤中的表达及意义．方法：采用ＳＡＢＣ免疫组化方法观察了７１例上皮性卵巢肿瘤标本中Ｂａｘ的表达．结果：Ｂａｘ在恶性、交界性及良性卵巢肿瘤中的阳性率分别为４０．５％，６２．５％和３８．９％，三者无明显差异（Ｐ＞０．０５），早期及晚期卵巢癌的阳性率分别为５０．０％和３７．９％，二者无显著差异（Ｐ＞０．０５），在Ｉ～ＩＩ病理分级中的阳性率分别为６６．７％，４０．０％和２３．１％，Ｉ与ＩＩ级间差异显著（Ｐ＜０．０５）．结论：ｂａｘ在上皮性卵巢癌中有高表达，Ｂａｘ的表达与肿瘤的病理分级成反比。

Aim: To investigate the expression of proapoptotic gene bax and evaluate its oncogenesis significance. Methods: Seventy one samples of epithelial ovarian tumour specimens were analyzed by SABC immunohistochemical stain for proapoptotic Bax protein expression. Results: The positive rates of Bax expression among the malignant,borderline and benign tumours were 40.5%, 62.5% and 38.9% respectively, and no significant difference was observed ( P >0.05).The positive rates of Bax expressions of early and late stages of cancer were 50.0% and 37.9% respectively, with no significant difference ( P >0.05); the Bax expression rates among pathologic grades I, II and III were 66.7%, 40.0% and 23.1% respectively, with significant difference between grades I and III ( P <0.05). Conclusion: There is an overexpression of Bax in epithelial ovarian cancer. The positive rate of bax is lower in pathologic grade Ⅲ than in grade I, while the proportion of expression of Bax in malignant and benign tumours as well as the clinical stages of cancer has not been observed.