摘要
HCV是丙型肝炎的致病体,在被感染组织和血清中浓度较低,病毒高度变异及缺乏稳定的体外细胞培养系统及理想的实验动物模型等问题,阻碍了对HCV的进一步研究。近年来各种HCV体外培养系统的建立,为HCV的研究提供了强有力的工具,使人们对HCV的认识提升到新的层次。本文就CD81、低密度脂蛋白受体、清道夫受体B1及Claudin-1等受体及入胞相关分子研究进展作一简要综述。
HCV is the pathogen of hepatitis C. The study on HCV has been hampered by low HCV concentration in the infected tissues and the serum, high viral mutation rates, and the lack of stable in vitro cell culture systems and ideal experimental animal models. In recent years, a variety of HCV in vitro cell culture systems provides a powerful tool for HCV study, which greatly promotes the recognition of HCV to a new level. This article makes a brief review of the study on HCV receptors, such as CD81, low-density lipoprotein receptor, scavenger receptor class B type 1, Claudin-1, etc., and molecules associated with the entry of HCV into host cells.
出处
《传染病信息》
2009年第4期250-254,共5页
Infectious Disease Information
基金
国家自然科学基金项目(30771891)
关键词
丙型肝炎病毒
受体
入胞
hepatitis C virus （HCV）
receptor
entry molecule
