新生儿高胆红素血症与心肌损害的关系研究

The myocardium damage of neonatal hyperbilirubinemia

目的:探讨新生儿高胆红素血症患儿心肌酶与心肌损害的关系。方法:选择50例新生儿高胆红素血症组(治疗组)及生理性黄疸20例(对照组),治疗前后测定所有患儿的血清心肌酶及其同工酶活性。结果:高胆红素血症患儿心肌酶及同工酶活性均有不同程度增高,乳酸脱氢酶(LDH)、肌酸激酶(CK)、天冬氨酸转氨酶(AST)、肌酸激酶心肌同工酶(CK-MB)在高胆红素血症治疗组和对照组之间相比有显著差异(P<0.01),治疗前后差异有统计学意义(P<0.01)。结论:新生儿病理性黄疸可出现心肌损害。

Objective： To discuss the relation between myocardial zyme and myocardium damage of neonates hyperbilirubinemia. Methods： Fifty neonates with hyperbilirubinemia, 20 neonates with physiologic jaundice were enrolled, enzymic activity be fore and after were detected. Results： There was significant difference of LDH, CK, AST, CKMB between two groups （P〈0.01）, also between before and after. Conclusion： There were damages to myocardium in neonates with hyperbilirubinemia.