胶原蛋白和弹力蛋白在血管组织工程中的应用

Application of collagen protein and elastin in blood vessel tissue-engineering

胶原蛋白和弹力蛋白是细胞外基质的2个非常重要的组成成分，不同的细胞外基质对于内皮细胞生长和组织再生都有很重要的作用。胶原蛋白是构成细胞外基质的骨架结构，用不同的方法将胶原与不同的物质聚合可以得到不同机械性能和生物特性的血管支架。胶原蛋白作为一种促凝剂，利用一定的方法尽量避免组织血管中胶原蛋白的暴露，可以防止工程血管的血栓形成，胶原交替联接和胶原袖套混合物可以加强支架替代物的机械强度；弹力蛋白是血管的重要的结构和起重要调节作用的基质蛋白，赋予血管壁弹性和良好生物学特性，用于支架和包被支架材料方面显示出巨大的应用潜能。

Collagen protein and elastin are two of the most important components of extracellular matrix.Different extracellular matrix play important role in endotheliocyte growth and tissue regeneration. Collagen protein as skeleton structures of extracellular matrix, combined with different materials and in different ways, results in intravascular stent substitutes with different manchnical strength and biological characteristics. Collagen as a coagulator that concealed by some methods can avoid thrombosis. The cross-linked collagen and the collagen oversleeve mixture used in scaffolds may strengthen the substitutes. Elastins are important structure of blood vessel and play important rote in maintaining the elasticity and bionomics of blood vessel, and thus have a tremendous application potential as scaffolds and coating scaffolds materials.