MAPK信号转导通路及其在脂肪分化中的作用

MAPK Signal Transduction Pathway and its Effects on Adipose Cell Differentiation

丝裂原活化蛋白激酶(MAPK)信号转导通路是真核细胞将胞外信号转导至胞内引起细胞反应的一类重要信号系统。此通路通过影响基因的转录和调控,参与调节细胞增殖、分化、转化、凋亡及细胞间的功能同步等一系列生命活动。肥胖已经成为危害人类健康的重要问题,是许多疾病的独立危险因素。探讨脂肪细胞分化及其调控机制对相关疾病的预防和治疗具有十分重要的意义。MAPK信号转导通路在脂肪细胞分化中发挥重要作用。ERK1/2,JNK和p38MAPK三条通路通过独立作用及复杂的协调作用,参与调控脂肪细胞分化过程的各个环节,其调节作用具有多样性。

MAPK signal transduction pathway is an important signaling system which induces cellular reaction by transducing extracellular signals into cell in eukaryotic cells. It is involved in the modulation of many life activities, such as cell proliferation, differentiation, transformation, apoptosis, and cell synchronization through the influence of gene transcription and regulation. As an independent risk factor of many diseases, obesity is becoming a serious threat to human health. Investigations of adipose cell differentiation and its regulation mechanisms are significant to the prevention and treatment of related diseases. MAPK signal transduction pathway plays an important role in adipose cell differentiation. And ERK1/2, JNK and p38 MAPK pathways participate in the regulation of every link of adipose cell differentiation through their independent roles and complicated coordination, with the regulatory diversity.