酚类化合物对发光菌的联合毒性

The Joint Toxicity of Phenols to Photobacterium phosphoreum

以发光菌为受试生物,测定苯酚和19种取代酚类化合物在pH=7.0时的单一毒性,以及等毒性单位配比下二元混合物的联合毒性.采用毒性单位、相加指数、混合毒性指数和相似性参数4种方法对联合毒性进行评价,并探讨联合毒性效应的作用机理.结果表明,苯酚与其他酚类化合物组成的二元混合物对发光菌的联合作用类型大部分表现为协同作用,小部分表现为拮抗或部分相加作用.对于同一联合作用,采用不同的评价方法,其评价结果会稍有差异.

The single toxicity of phenol and 19 phenols to Photobacterium phosphoreum were determined respectively under pH= 7.0. The binary joint toxicity examinations were performed for phenol and substituted phenols under the concentration ratio of equal toxic unit. Toxic unit method, additive index method, mixture toxicity index method and similarity parameter method were used to evaluate the joint toxicity. And the mechanism of joint toxicity was also investigated. The results showed that the binary mixtures of phenol and other substituted phenols mostly were synergistic effect and only a few were antagonistic or partly additional effect. For the same joint actions of binary mixtures of phenol and substituted phenols, the evaluated results of joint action types varies slightly with different evaluating methods.