摘要
以邻苯二甲酰亚胺、1,3-丙二胺、1,4-丁二胺为原料,合成了5个邻苯二甲酰亚胺-多胺缀合物.所合成的目标化合物经过1HNMR、13C NMR、MS、元素分析确认,并评价了它们对K562(人慢性原白血病细胞)、MB231(乳腺癌细胞)、LnCap(前列腺癌细胞)的生物活性.结果表明:5个目标化合物均不具备抗肿瘤活性,提示多胺衍生化不能提高邻苯二甲酰亚胺的抗肿瘤活性.
In order to search for antitumor drugs with high activity and low toxicity, five novel phthalimide polyamine conjugates were synthesized and their structures confirmed by ^1 H NMR, ^13C NMR, MS and elemental analysis. The preliminary in vitro antitumor activities against human leukemia K562, MB231 and LnCap cell lines demonstrated that the presence of polyamine motif can＇t possess elevated potency and specificity against the tested tumor cells.
出处
《化学研究》
CAS
2009年第3期33-37,共5页
Chemical Research
基金
河南省重点科技攻关项目(082102270002)
