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慢性束缚应激性抑郁与雌性小鼠雌激素和海马雌激素受体的关系 被引量:3

Relationship of depression-like behavior induced by chronic restraint stress estrogen and hippocampal estrogen receptor of female mice
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摘要 采用慢性束缚应激抑郁模型,通过强迫游泳测试(Forced swimming test,FST)和免疫组织化学方法,探讨了慢性束缚应激对雌性小鼠海马雌激素受体(Estrogen receptor,ER)和行为表现的影响.结果显示:与对照组相比,慢性束缚应激小鼠的体重降低或增长速度明显减慢,FST不动时间增长(P<0.01),ER表达下降(P<0.01);卵巢切除后的小鼠在行为表现和ER表达与慢性束缚应激组的结果相似;与应激组相比,应激同时周期性外源补充雌激素,小鼠体重增长速度加快,FST不动时间明显减少(P<0.01),而ER表达明显下降(P<0.01).结果表明,慢性束缚应激能诱发抑郁,慢性束缚应激性抑郁发生与雌激素水平及雌激素受体下降有关. To observe the effects of chronic restraint stress(CRS)on the expression of estrogen receptor(ER)in hippocampus of female and behavioral changes,female mice were selected,the animal depression model related chronic restraint stress was used,and forced swimming test(FST)was carried out to observe their behaviors.Immunohistochemistry was used to observe the expression of ERα and ERβ in hippocampus.Chronic restraint stress could notably restrain the augment of animal weights and increase their immobility time in FST.Compared with control group,there were significant reduction in the number of ERα-IR cells,ERβ-IR cells in hippocampus in CRS group.OVX could also notably restrain the augment of animals weight and increase their immobility time in FST.Compared with control group,there were significant increase in the number of ERα-IR cells in the DG,and significant reduction in that of ERβ-IR cells in the CA1,CA2,CA3 in OVX group.During the course of chronic restraint stress,female mouse were injected with E periodically,and we found that animal weights were notably increased and their immobility time was reduced remarkably compared with Stress group.Additionally,there were significant reductions in the number of ERα-IR cells and ERβ-IR cells in the hippocampus.Chronic restraint stress can lead to depression-like behavior,and there is a close relationship between stress-induced depression and estrogen.
出处 《陕西师范大学学报(自然科学版)》 CAS CSCD 北大核心 2009年第4期82-87,共6页 Journal of Shaanxi Normal University:Natural Science Edition
基金 陕西省自然科学基金资助项目(2006C240)
关键词 雌激素 慢性束缚应激 抑郁 海马 estrogen chronic restraint stress depression hippocampus
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  • 1喻东山.性激素和抑郁症[J].国外医学(精神病学分册),1999,26(2):111-112. 被引量:24
  • 2Nestler E J, Barrot M, Dilenonei R J, et al. Neurobiology of depression [J]. Neuron, 2002, 34: 13- 25.
  • 3Kendler K S, Karkowski S L. Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment [ J ]. Psychological Medicine, 1997, 27: 539-547.
  • 4张艳美.慢性应激、大脑损害与抑郁症[J].国外医学(精神病学分册),2001,28(2):105-109. 被引量:75
  • 5Porsolt R D, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants [J]. Archives Internationales de Pharmacodynamie et de Therapie, 1977, 299(2): 327-336.
  • 6曹碧茵,施建蓉,童瑶,邹军.心理应激动物模型的研制及其应用[J].中国行为医学科学,2005,14(2):191-192. 被引量:29
  • 7Pham K, Nacher J, Hof P R, et al. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus [J]. The European Journal of Neuroscience, 2003, 17: 879-886.
  • 8徐建芬.慢性束缚应激损害小鼠学习记忆和抑制体重增加[J].浙江教育学院学报,2004(5):23-27. 被引量:8
  • 9Bowman R E, Ferguson D, Luine V N. Effects of chronic restraint activity, spatial neurotransmitters stress and memory, estradiol on open field and monoaminergic in ovariectomized rats [ J ]. Neuroscience, 2002, 113(2): 401-410.
  • 10Matthews K, Forbes N, Reid I C. Sucrose consumption as an hedonic measure following chronic unpredict- able mild stress[J]. Physiology & Behavior, 1995, 57 : 241-248.

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  • 1张华娜,郑晖.慢性应激对大鼠海马长时程增强和氨基酸神经递质的影响(英文)[J].中国临床康复,2006,10(6):176-178. 被引量:5
  • 2李则宣,李凌江.不同刺激对条件性恐惧大鼠行为及海马CA1区突触可塑性的影响[J].中华精神科杂志,2006,39(1):42-46. 被引量:5
  • 3A.D.Green,L.A.Galea.Aduh hippocampal cell proliferation is suppressed with estrogen withdrawal after a hor- mone-simulated pregnancy [J].Horm Behav, 2008,54 ( 1 ) : 203-211.
  • 4L.A.Galea, J.K.wide,A.M.Barr.Estradiol alleviates depres- sive-like symptoms in a novel animal model of post-partum depression[J].Behav Brain Res, 2001,122( 1 ) : 1-9.
  • 5I.Jones, F.Middle, F.McCandless, et al.Molecular genetic studies of bipolar disorder and puerperal psychosis at two polymorphisms in the estrogen receptor alpha gene(ESR 1 ) [J].Am J Med Genet, 2000,96(6 ) : 850-853.
  • 6C.M.Leite, R.E.Szawka, J.A.Anselmo-Franci.Alpha-oestro- gen and progestin receptor expression in the hypothalamus and preoptic area dopaminergic neurones during oestrous in cycling rats[J].J Neuroendocrinol, 2008,20( 1 ) : 110-119.
  • 7W.R.Perlman, M.J.webster, J.E.Kleinman, et al.Reduced glucocorticoid and estrogen receptor alpha messenger ri- bonucleic acid levels in the amygdala of patients with major mental illness[J].Biol Psychiatry, 2004,56( 11 ) : 844-852.
  • 8M.K.Osterlund, M.R.witt,J.A.Gustafsson.Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties-the next generation of therapeutics[J].Endocrine, 2005,28(3 ) : 235-242.
  • 9李伟,唐晓伟,林圣彬,周鸿铭,鲁亚平.雌激素受体α在抑郁症模型大鼠海马中的分布[J].安徽师范大学学报(自然科学版),2010,33(1):62-66. 被引量:12
  • 10代兰芬,陈华丽,李节,乔桂圆.产前抑郁症对孕妇睡眠质量的影响研究[J].护理管理杂志,2014,14(2):86-87. 被引量:15

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