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选择性钙通道阻滞剂构效关系及其作用的研究进展

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摘要 钙拮抗剂又称钙通道阻滞剂fcalcium channel blocker，CCB），是指在通道水平上选择性阻滞钙离子进入细胞内。降低细胞内钙离子浓度的一类药物。早在18世纪后期。钙离子内流可引起肌肉收缩已为人所知，但对其进入细胞的机制尚不清楚。1963年Knoll和Hoechest公司首次合成钙通道阻滞剂维托帕米，为心脑血管疾病的治疗翻开了崭新的一页。细胞内钙有极其重要的生理功能，
作者 杨梅 李胜娟 张永健
机构地区 河北省邢台医学高等专科学校 河北省邢台市妇幼保健院药剂科 河北省医科大学
出处 《中国民族民间医药》 2009年第17期4-6,共3页 Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词 选择性钙通道阴滞剂构效关系 作用 研究进展
分类号 R287 [医药卫生—中药学]
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参考文献38

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中国民族民间医药
2009年 第17期

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