441例药品不良反应报告分析

Analysis of 441 Case of Adverse Drug Reactions

目的了解药物不良反应(ADR)的特点及表现。方法对本院2003年10月至2008年11月收到的441例ADR报告进行回顾性分析。结果441例ADR报告中涉及的药品(不含输液)有107个品种,其中抗微生物药340例,占77.1%,中药注射剂35例,占7.9%;静脉滴注的ADR发生率最高,占85.5%。在ADR累及的器官中,皮肤黏膜比例最高。结论药物不良反应的发生与多种因素有关,积极开展ADR监测工作,促进临床合理用药,降低ADR发生率。

Objective To investigate the characteristic and clinical impacts of the adverse drug reactions （ADRs） in our hospital. Methods A total of 441 cases of ADR reports that were received in our hospital from October 2003 to November2008 were analyzed retrospectively. Results The 441 cases of ADR reports related to （excluding infusion） 107 species of drugs, of which 340 cases of anti - infective drugs, accounting for 77. 1% ; 35 cases of traditional Chinese medicine injection, accounting for 7.9% ; intravenous administration had the highest incidence of ADR, accounting for 85.5%. Skin mucous membrane is the most frequently affected organ by ADR. Conclusion The occurrence of ADR has a variety of factors, we should actively monitor ADR and promote rational use of medicine in clinical, so as to reduce the occurrence of ADR.