巨块型肝癌大剂量碘化油介入栓塞的疗效分析

The utility of large dosage lipiodol treatment in huge primary hepatic carcinoma

目的回顾性分析巨块型肝癌经肝动脉灌注化疗并大剂量碘化油加化疗药栓塞治疗的临床疗效。方法115例巨块型肝癌患者,肿块大小为7～16cm,经肝动脉灌注化疗并碘化油加化疗药物栓塞,碘化油用量为20～40mL。结果治疗的总有效率(RR)为73.9%(85/115),治疗后1、2、3年生存率分别为71.3%、39.1%、8.7%,介入术后未出现严重并发症。结论巨块型肝癌经肝动脉灌注化疗并碘化油加化疗药栓塞治疗的疗效较好,不良反应少。

Objective To investigate the clinical efficacy of transcatheter arterial chemoembolization （TACE） with large dosage iodized oil （lipiodol） in huge primary hepatic carcinoma （PHC） via injecting from hepatic artery. Methods One hundred and fifteen cases with huge PHC, tumor size of 7-16 cm, received 20-40 mL lipiodol injection in each TACE case. Results The overall response rate was 73.9%, the 1, 2, 3 years survival rates after treatment were 71.3%, 39.1%, 8.7%. No severe complications happened in this series. Conclusion It is effective and safe for patients with huge PHC to receive TACE with large dosage lipiodol embolization.