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轻度阿尔茨海默病患者视网膜形态改变的观察 被引量:5

Morphological change of retina in mild Alzheimer's disease
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摘要 目的:通过观察轻度阿尔茨海默病(AD)患者的视神经纤维层厚度来评估视网膜形态改变。方法:比较15例轻度AD患者和15例对照组视网膜的形态差异。通过光学相干断层成像(OCT)测定视网膜上方、下方、鼻侧和颞侧的视神经纤维层的厚度,比较两组的差异。结果:AD患者的视神经纤维层的厚度与对照组相比,在各象限的数值和均值均显著减少(P<0.01)。结论:在轻度AD患者中视神经纤维层的厚度的减少提示在疾病早期即存在视网膜形态改变,OCT可能作为辅助手段有助诊断。 Objective To examine the optic nerve fiber layer thickness for assessing the morphological change of the retina in patients with mild Alzheimer's disease (AD). Methods Fifteen mild AD patients and 15 age-matched healthy controls were enrolled in this study. Retinal nerve fiber layer (RNFL) thickness was measured by optical coherence tomography (OCT). The measurement was performed in each quadrant (superior, inferior, nasal and temporal). Results In AD patients, there was a significant reduction of RNFL thickness in each of the quadrants when compared with that in healthy controls (P〈0.01). Conclusions These results indicate that there is a reduction of RNFL thickness in mild AD patients, which suggests that morphological change of retina already occurs in the early stage of AD, and OCT can be used as an adjuvant approach for helping the diagnosis of morphological change of retina in AD.
出处 《诊断学理论与实践》 2009年第4期397-400,共4页 Journal of Diagnostics Concepts & Practice
关键词 阿尔茨海默病 视网膜 光学相干断层成像 Alzheimer's disease Retina Optical coherence tomography
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  • 1Tian Tian 1, Xiao-Hua Zhu 2, Yun-Hai Liu 1 1Department of Neurology, Xiangya Hospital, Central-South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China 2Department of Ophthalmology, the Second Xiangya Hospital, Central-South University, 139 Renmin Middle Road, Changsha 410011, Hunan Province, China.Potential role of retina as a biomarker for progression of Parkinson's disease[J].International Journal of Ophthalmology(English edition),2011,4(4):433-438. 被引量:7
  • 2彭丹涛,许贤豪,刘江红,矫玉娟,张华,殷剑,孟晓梅,谢琰臣,冯凯.简易智能精神状态检查量表检测老年期痴呆患者的应用探讨[J].中国神经免疫学和神经病学杂志,2005,12(4):187-190. 被引量:151
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