PARs与消化系肿瘤关系的研究进展

Advances in the relationship between protease-activated receptors and digestive system tumors

蛋白酶激活受体(protease-activated receptor,PARs)家族是一类与G蛋白相偶联、有7个跨膜单位的受体家族,广泛分布于消化系统脏器及组织.PARs与消化系肿瘤关系密切,主要表现在PARs在肿瘤组织中高表达,其表达与肿瘤的恶性程度及侵袭转移能力正相关性.体外研究表明,利用PARs的激动剂干预肿瘤细胞,可加强其增殖、侵袭转移能力.PARs对肿瘤细胞增殖、侵袭能力的调控依赖于多种信号转导途径,其作用机制尚不明确,现就此作一综述.

Protease-activated receptors（PARs）,belonging to a family of G-protein-coupled seven-transmembrane-domain receptors,are widely distributed in digestive organs.PARs are highly expressed in digestive system tumors,and their expression is positively correlated with the malignancy, invasiveness and metastasis of digestive system neoplasm.PAR agonists are able to promote the proliferation,invasion and metastasis of tumor cells in vitro.The role of PARs in tumor cells depends on a variety of signal transduction pathways. However, the mechanism underlying their role in the proliferation, invasion and metastasis of tumor cells remains unclear. In this article, we will review their role in the development and progression of digestive system tumors and the molecular mechanism underlying such role.