469例乳腺肿物针吸细胞学与组织学的对照分析

Fine needle aspiration cytological diagnosis of breast masses:a comparative analysis of cytology and histology in 469 cases

目的探讨乳腺肿物针吸细胞学（FNAC）形态学特点与组织学的关系。方法对1149例乳腺肿物患者行FNAC检查,其中469例获得组织病理学对照。结果469例中,211例针吸涂片多数性质相同的病例显示具有相对一致的形态学特征;237例恶性肿瘤诊断的敏感性为92%,232例良性病变诊断的特异性为92.7%,总准确率为92.3%;假阴性率为8%,潜在假阳性率为7.3%,总误诊率为7.7%,无假阳性报告。结论结合病史、临床触诊及穿刺针感对乳腺肿物做出综合判断更有利于乳腺肿物FNAC诊断。

Objective To study the significance of morphological characteristics, palpation and puncture sense of fine needle aspiration cytological （FNAC） diagnosis of breast masses. Methods A total of 1149 FNAC cytology cases of breast were performed, in which 469 cases were compared with their histological diagnosis. Results Of the 211 FNAC cases, relatively identical morphological features were found on the smears of lesions of the same nature. The sensitivity of diagnosis in 237 cases of malignant tumor, the specificity of diagnosis in 232 cases of benign lesion and the overall accuracy of diagnosis were 92%, 92.7% and 92.3%, respectively. The false negative rate, potential false positive rate and the overall misdiagnosis rate were 8%, 7.3 % and 7.7 % respectively, and no false positive diagnosis case was found. Conclusion General evaluation of breast masses combined with clinical history, palpation and sense of ptmcture will facilitate the differential diagnosis.