砂粒体在甲状腺癌研究中的进展

Progress of thyroid cancer and psammoma body

甲状腺癌占头颈部恶性肿瘤发病率的首位,并且随着高频超声、细针穿刺、PET-CT等诊断技术的发展,甲状腺微癌检出率有所提高,近十年来甲状腺癌发病人数有急剧上升的趋势。砂粒体作为乳头状肿瘤中的特殊病理结构,并在影像学上表现为微小钙化,对于甲状腺癌,特别是甲状腺乳头状癌原发灶及转移灶的病理学、细胞学、以及影像学诊断具有重要的意义。认识其本质及形成机制对于甲状腺癌的鉴别诊断具有重大的意义。本文总结了砂粒体在甲状腺癌诊断中的应用以及砂粒体形成机制研究中的最新进展。

Thyroid carcinoma is one of the most common diseases in the head and neck area. With the advance of innovative technologies like ultrasound ,fine-needle aspiration and PET-CT, the number of patients diagnosed as thyroid carcinoma has grow rapidly during the past ten years. As a special structure in papillary tumors and appearing as microcalcification in the imaging examination, psammoma body has been considered of great significance in the diagnosis of thyroid carcinoma. Psammoma body has unique features in terms of pathology, cytology and imageology. The study of the mechanism of psammoma body formation is very important for the clinic to differentiate the disease from others. In this article, we summarized the role of psammoma body in the study of thyroid cancer.