血必净注射液对老年多器官功能障碍综合征胃肠功能障碍的治疗作用

Xuebijing in the treatment of gastrointestinal dysfunction among elderly cases with multiple organ dysfunction syndrome

目的观察血必净治疗老年多器官功能障碍综合征胃肠功能障碍的临床疗效。方法采用前瞻性、多中心、临床随机对照研究方法，将58例老年多器官功能障碍综合征患者随机分为血必净治疗组和对照组，于治疗前以及用药后7d对患者进行胃肠功能评分、胃肠功能疗效、急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分和MarshaⅡ评分，28d的转归情况。结果两组治疗后胃肠功能评分、APACHEⅡ评分及MarshaⅡ评分均有所降低，且治疗组较对照组改善更为明显，差异均有统计学显著性。治疗组胃肠功能疗效较对照组增加，改善更为明显，差异均有统计学显著性。治疗组28d后APACHEⅡ评分在8～20分间的患者病死率较对照组显著降低。结论血必净能够改善老年多器官功能障碍综合征患者的胃肠功能和病情严重度及预后。

Objective To observe the clinical effect of Xuebijing in the treatment of gastrointestinal dysfunction among elderly cases with multiple organ dysfunction syndrome （MODS）. Methods Multicenter, randomized and control test was applied to 58 elderly patients with MODS who were assigned randomly to administration of Xuebijing group or control group. The intestinal dysfunction score, acute physiology and chronic health evaluation Ⅱ score （APACHE Ⅱ ） and MarshaⅡ score were calculated before and after the test respectively. The prognosis within 28 d was recorded. Results The intestinal dysfunction score, APACHE Ⅱ score and Marshall score of all patients were decreased in both groups, but they were significantly better in treatment group than those in the control group. The effect on intes- tinal dysfunction was better in Xuebijing group. There was significant difference on the mortality in treatment group compared with that in the control group when APACHE Ⅱ was between 8 and 20 scores. Conclusion Xuebijing can improve gut barrier function and the prognosis of the elderly patients with MODS.