慢性咽炎合剂长期毒性试验研究

Study on Chronic Toxicity Test of Slow Pharyngitis Mixture

目的观察慢性咽炎合剂的长期毒性反应。方法大鼠连续56 d经灌胃给予慢性咽炎合剂,给药后一半动物进行病理、血液学和血液生化学检查,另一半动物停药观察2周,进行上述同样的检查。结果大鼠毛发光泽、活动自如、外观、摄食和粪便等均未见异常,体质量增加与对照组比较无显著性差异;心、肝肾、肾上腺、脾、肺、睾丸和卵巢的脏器系数与对照组比较均无显著性差异;血液生化指标-葡萄糖(GLU)、尿素氮(BUN)、肌酐(Crea)、总胆固醇(T-CHOL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)、总胆红素(T-B IL)和碱性磷酸酶(ALP)与对照组比较均无显著差异;尸检动物重要脏器未见明显病理变化。结论慢性咽炎合剂长期毒性试验未见异常反应,临床上应用本品是安全的。

Objective To observe the chronic toxicity of Slow Pharyngitis Mixture. Methode After keeping on garaing rat with Slow Pharyngitis Mixture for 56 clays （ once a day）, perform the test of pathology, haematology, and biochemistry of blood. Then stop garaging for 2 weeks, and the same tests are perfomed again. Results The rat had no adnormal changes in the bite and sup, activity, psychosis, coat and skin, urine and faeces , and body weight. The organ index of heart, hepar, kidney, adrenal, sleen, lung, testis and ovarium was not significantly comparable with normal group. The consentration of glucose（ GLU）, urea nitrogen （BUN）, creatinine （ Crea）, total cholesterin （ T-CHOL）, glutamic pyruvic transaminase （ ALT）, glutamic oxaloacetic transaminase（AST） ,total protein（ TP）, albumen（ALB） ,total bilirubin（T-BIL） and alkaline phosphatase（ALP） in serum was not significantly comparable with normal group. There were no remarkable pathological changes in all organs of rat. Conclusion There are no abnormal changes in chronic toxicity trial with Slow Pharyngitis Mixture. Slow Pharyngitis Mixture is safe in clinic use.