神经干细胞移植治疗脑出血后遗症

Clinnical analyisis of neural stem cells transplantation for treatment of sequela in 3 cerebral hemorrhage patients

目的观察应用神经干细胞移植治疗改善脑出血后遗症患者功能独立性的临床疗效。方法选择神经外科2006年1月至2008年9月收治的患者3例,男2例,女1例,平均62岁,其中基底节出血术后2例,丘脑出血1例。在无菌条件下,从患者的髂后上棘抽取骨髓血60~90 ml,分离纯化成干细胞,3例患者均在局麻下行腰椎穿刺蛛网膜下腔植入神经干细胞,每周一次,共计3次。采用神经功能缺损评定评分对患者术前、术后6个月进行评定。主要评价:智力,计算能力,言语功能,对外界反应的灵敏性,吞咽功能,肌张力,肌力。结果自体移植后8 h^5 d内,3例中有两例出现发热,体温在37.6°C^38.2°C之间。治疗后观察随访2~5个月,智力改善2例,肌力增加3例,吞咽改善1例,言语功能改善3例,计数能力改善2例。结论神经干细胞移植对改善脑出血后遗症有效,患者生存质量提高。

Objective To abserve the curative effect of neural stem cells transplantation on sequela of cerebral hemorrhage patients. Methods We chose 3 patients with cerebral hemorrhage who received the treatment in our hospital from janrary 2006 to setember 2008. there were 2 male and lfemal with the average of 62 years. Among them, basal ganglia hemorrhage was in 2 cases, thalamencephalon hemorrhage patients in 1 case, neural stem cells were transplanted into all the patients through lumbar acupuncture at subarachnoid space , oncr a week,3 times in total, To use function Independence scoring to evaluate self care, Intellectual function, Calculations ability, speech ability, comprehension and communication ability, swallowing ability, muscle mass, strength. Results Two patients appeared fever between 8 hours to 5 days after transplantated, the tempreture was 37.6℃-38. 2℃ ,followed-up for two and five months after transplantated, Intellectual improved in 2 cases, strength, improved in 3 cases, swallowing ability improved in 1 case, speech ability improved in 3 cases, Calculations ability improved in 2 cases Conclusion Transplantation of neural stem cells can improve the sequela of cerebral hemorrhage patients and improve the living quality of patients.