齐拉西酮与氯氮平对首发精神分裂症患者生活质量影响

Comparative study on the influence of Ziprasidone and clozapine on quality of life in schizophrenic

目的探讨齐拉西酮治疗对首发精神分裂症患者生活质量的影响。方法以齐拉西酮与氯氮平治疗精神分裂症各40例作对照研究,采用简明精神病评定量表(BPRS)不良反应量表(TESS)评定疗效及不良反应,WHOQ0L-BREF量表衡量患者的生活质量。结果最后一次评定,齐拉西酮组BPRS总分降至(15.62±4.37),与治疗前比较有显著性差异(P<0.01);氯氮平组BPRS总分降至(16.02±4.63),与治疗前比较有显著性差异(P<0.01)。两组间疗效无显著性差异(P>0.05)。氯氮平组毒副作用较齐拉西酮组多。经6个月治疗,齐拉西酮组的身心健康、心理健康、社会关系、环境因素的分值分别为(72.43±4.53),(94.87±10.55),(96.31±12.37),(95.43±10.12),氯氮平组的身心健康、心理健康、社会关系、环境因素的分值分别为(69.81±5.37)、(79.72±11.84)、(80.72±11.42、77).(74±10.56)。两组患者生活质量较治疗前均有显著改善(P<0.01),在心理健康、社会关系和环境因素等三方面,齐拉西酮优于氯氮平(P<0.01)。结论首发精神分裂症患者在提高患者生活质量方面,齐拉西酮优于氯氮平,有利于精神分裂症的远期康复。

Objective To investigate the influence on quality of life of Ziprasidone in schizophrenia Methods 40 schizophrenic patients were treated with ziprasidone as the controlled group. The Brief Psychiatric Rating Scale （ BPRS）, while the adverse events were determined by the treatment emergent symptoms scale （TESS）, WHOQOL-BREF instruments were used to evaluate the patients quality of life before and after drug administration. Results For the last assessment ,The scores of BPRS decrease to （ 15.62 ± 4. 37 ） in Ziprasidone group, was significantly lower than the beginning （P 〈0. 01 ） ; the scores of BPRS decrease to（ 16.02 ± 4.63） in clozapine group, was significantly lower than the beginning （ P 〈 0. 01 ） ; Two groups showed similar effects, with no significance. The side effects were more in clozapine group than those in Ziprasidone group. 6 months after treatment, the scores of physical health, psychological health, social relationship, and environment in Ziprasidone group were （ 72.43 ± 4. 53 ）, （ 94. 87 ±10. 55 ）, （ 96. 31 ±12. 37 ）, （ 95.43 ±10. 12 ） ; And the scores of physical halth, psychological health, social relationship, and environment in clozapine group were （69.81±5.37）, （79.72± 11.84）, （80.72 ±11.42）, （77.74± 10.56）. The scores of four domains in WHOQOL-BREF instruments had been improved significantly in two groups （P 〈0.01 ） In the mains of Psychological health, social Relation ship and Environment, Ziprasidone was superior to clozapine （P 〈 0.01 ）. Conclusion Ziprasidone has more advantage than Clozapine to improve quality of life in schizophrenic and would be helpful to patients longterm rehabilitation.