直肠癌术后复发的预防性治疗分析

Clinical observation of the precautional therapy for rectal cancer of postoperative recurrence

目的探讨放射治疗结合化疗预防性治疗直肠癌术后复发的疗效。方法回顾分析120例采用Mile’s和Dixon术式的结直肠癌患者,随机分为观察组60例和对照组60例,分别给予化疗联合放疗与单纯化疗,观察临床疗效、不良反应发生情况与复发率。结果观察组60例1/2、1年的局部复发率为1.67%、3.33%;对照组为8.33%、15%。两组1/2年局部复发率的差异无统计学意义,1年局部复发率的差异具有统计学意义。结论应用氟尿嘧啶化疗结合放疗的预防性治疗对防治直肠癌术后复发有积极的临床意义。

Objective To evaluate the effects of radiotherapy combined with chemotherapy for rectal cancer of postoperative recurrence. Methods One hundred rectal cancer patients with Mile＇ s and Dixon were divided randomly into two groups ： 60 cases （ obseveration group） received CRT plus chemotherapy, 60 cases （ comparison group）received conventional chemotherapy. Results The follow-up data were completely collected from 100 cases. The 1/2,1 year local recurrence of obseveration group and comparison group were 1.67% , 8.33%and 8.33%, 15% respectively. Conclusion Radiotherapycombined with chemotherapy as precautional therapy can be considered as an effective and feasible approach to rectal cancer patients of postoperative local recurrence.