姜黄素前体药物FM0806的初步稳定性及其水解动力学

Study on the stability of curcumine prodrug FM0806 and its hydrolysis kinetics

目的研究姜黄素前体药物的稳定性及其水解动力学。方法利用HPLC法测定FM0806在不同pH值的缓冲溶液、血浆及肝匀浆中药物水解动力学。结果姜黄素前体药物FM0806在pH为2—10时水解速率常数不受pH影响，而在血浆及肝均浆中刚0806可迅速水解。结论FM0806是一个具有良好前景的姜黄素前体药物。

Objective To investigate the stability and the kinetic of curcumine prodrug FM0806. Methods Prodrug hydrolysis was studied in aqueous buffer solutions with pH 2-10 as well as 80% rat plasma solution and homogenized liver by the reversed-phase high performance liquid chromatography （RP-HPLC） Method. Results The velocity of hydrolysis of FM0806 kept the same level under pH 2-10,and it could be hydrolyzed fast by enzymes in blood plasma, homogenized liver. Conclusions FM0806 was a promising prodrug of curcumine.