326株医院感染病原菌分布及耐药性分析

Distribution and Antibacterial Resistance of 326 Strains of Nosocomial Infection Pathogens

目的了解医院感染病原菌的分布及耐药情况。方法对医院2005-2007年医院感染病原菌来源及耐药性进行统计分析。结果在604例医院感染病例中分离出病原菌326株(54.0%),病原菌以革兰阴性菌为主,占44.1%,其次是真菌、革兰阳性菌,分别为41.6%、14.3%;位于前3位的病原菌分别为真菌41.6%、铜绿假单胞菌14.3%、肠杆菌属10.6%;大肠埃希菌对氨苄西林耐药率100.0%,MRCNS的检出率高达80.0%。结论真菌所占的比例过高,医院感染细菌的耐药性日趋严重,应引起高度重视。

OBJECTIVE To investigate the distribution and drug resistance of nosocomial infection pathogens. METHODS Statistical methods were used to analyz the data of pathogens origin and drug resistance from 2005 to 2007. RESULTS A total of 326 strains were isolated from 604 nosocomial infection cases （54.0 % ）, from which the Gram negative bacilli were predominate （44. 1%）. The isolation rate ot fungi and Gram-positie bacteria was 41.6V00 and 14. 3%, respectiviely. The top three pathogens were the fungi （41. 6%）, Pseudomonas aeruginosa 14.3%, and enterobacter （10.6%）. The rate of ampicillin-resistant Escherichia coli was 100%. The isolation rate of MRSA and MRCNS was up to 100.0% and 80.0%. CONCLUSIONS Fungi is common high among pathogens. The emergence of drug-resistant pathogens will continue to be a serious problem,we must take it intimately.