帕金森病患者体质研究

Constitutions of patients with Parkinson's disease

目的调查帕金森病(PD)患者体质特征,研究体质与证候的关系。方法采用脑内移植评分(CAPIT)以及统一帕金森病评定量表(UPDRS)和Hoehn-Yahr(H-Y)分级标准诊断、评价PD。中医师专人定式问卷调查症状和体质,采用《中华人民共和国国家标准:中医临床诊疗术语证候部分》诊断证候,按照王琦分型法分析诊断体质。并进行体质和证候的相关分析。结果125例PD病人中,阴虚质占52.8%,气虚质占18.4%,湿热质占12%,阳虚质占8.8%,痰湿质占8%。阴虚质与肝肾阴虚证(r=0.366,P<0.001)、脾肾阳虚证(r=-0.347,P<0.001)呈显著性相关;阳虚质与阴阳两虚证呈显著性相关(r=0.225,P<0.05);气虚质与脾肾阳虚证(r=0.228,P<0.01)、痰热动风证(r=0.202,P<0.05)、肝肾阴虚证(r=-0.225,P<0.05)显著性相关。结论阴虚质和气虚质为PD易患体质。阴虚质与肝肾阴虚证正相关;气虚质与脾肾阳虚证、痰热动风证正相关。

Objective To investigate the constitutional characteristics in patients with Parkinson＇s disease and study the relation between constitutions and syndromes. Methods The Intracerebral Transplantation Score Chart Grading Stan of TCM phys according to （CAPIT）, Unified Parkinson＇s Disease Rating Scale （UPDRS） and Hoehn-Yahr （H-Y） dard were applied to diagnose and review Parkinson＇s disease. The structured questionnaire ician was used to investigate the symptoms and constitutions. The syndromes were diagnosed State Standard of the People＇s Republic of China： Chinese Medicine Technical Terms for Clinical Diagnosis and Treatment-Chinese Medical Syndromes, and constitutions were analyzed and diagnosed based on WANG Qi＇s Constitutional Classification. The correlation between constitution and syndrome was analyzed. Results Among 125 patients the patients of yin-deficiency constitution accounted for 52. 8%, qi-deficiency constitution, 18. 4%, damp-heat constitution, 12%, yangdeficiency, 8. 8%, and phlegm-damp constitution, 8%. Yin-deficiency constitution was correlated significantly to yin deficiency syndrome of both liver and kidney （ r = 0. 366, P 〈 0. 001 ） and yang deficiency syndrome of both spleen and kidney （r = -0.347, P 〈0.001 ）. Yang-deficiency constitution was correlated significantly to deficiency syndrome of both yin and yang （ r = 0. 225, P 〈 0.05 ）. Qideficiency constitution was correlated significantly to yang deficiency syndrome of both spleen and kidney （ r =0. 228, P 〈0. 01 ）, syndrome of wind stirring induced by phlegm-heat （r =0. 202, P 〈0.05 ）, and yin deficiency syndrome of both liver and kidney （ r = - 0. 225, P 〈 0. 05 ）. Conclusion Yin-deficiency constitution and qi-deficiency cofistitution are common in the patients with Parkinson＇s disease. Yindeficiency constitution is correlated to yin deficiency syndrome of both liver and kidney, and qi-deficiency constitution is correlated to yang deficiency syndrome of both spleen and kidney and syndrome of wind stirring induced by phlegm-heat.