重度子痫前期的干预及治疗对策

The Intervention and Treatment on Severe Eclampsism

目的探讨重度子痫前期干预及治疗对策。方法对2003年1月至2008年10月住四川省医学科学院附属医院的238例重度子痫前期患者的临床资料进行回顾性研究。结果238例患者治疗后均痊愈出院,无孕产妇死亡。围生儿248例,存活226例,死亡22例,围生儿病死率8.87%。<34周重度子痫前期围生儿病死率高达34.29%,34周以后围生儿病死率明显降低,为11.76%,差异有统计学意义(P<0.01);且系统产前检查可降低重度子痫前期的发生率。结论重度子痫前期严重危害母婴健康,系统的产前检查和系统管理对预防和降低重度子痫前的发生起着重要的作用。早发型重度子痫前期在保证母亲安全前提下,积极的期待治疗至34周后以剖宫产终止妊娠结局较好。

Objective To explore intervention and treatment on severe eclampsism. Methods A respective study on clinical cases of 238 inpatients of severe eclampsism from Jan 2003 to Oct 2008 in affiliated hospital of medical science academy of Sichuan province. Results After treatment, 238 cases were cured without death. There were 248 perinatals, 226 survival, 22 died. The death rate of perinatal was 8.87%, compared with 34.29% of 34-week perinatal of severe eclampsism. After 34-week, the death rate of perinatal decreased obviously to 11.76%. There was statistically meaning between and after 34-week. Systematic prenatal examination can decrease the incidence rate of severe eclampsism （P 〈0.01）. Conclusion Severe eclampsism endangers maternal and infant health severely. Systematic prenatal examination and treatment can play important role in intervening and decreasing the happening of severe eclampsism. The early-onset severe eclampsism can get better ending with active treatment at the safety premise of maternal with cesarean section after 34-week pregnancy period.