高压氧治疗对重度脑挫裂伤患者血清神经元特异性烯醇化酶、血浆内皮素的影响

Effects of Hyperbaric Oxygenation on Blood Serum Neuron Specific Enolase and Endothelin among Patients with Severe Contusion and Laceration of Brain

目的:研究高压氧治疗对重度脑挫裂伤患者血神经元特异性烯醇化酶(N SE)、内皮素(ET)的影响。方法:患者随机分为高压氧治疗组36例和西药对照组33例。两组基础药物相同,治疗组采用高压氧治疗,比较两组的疗效及治疗前后N SE、ET的变化。结果:HBO组和对照组总有效率分别为97.2%和72.7%,N SE、ET下降治疗组均优于对照组,差异有统计学意义(P<0.01)。结论:高压氧通过增加供氧、调节血管功能、减轻脑水肿来保护神经细胞,降低患者N SE、ET水平,改善患者的神经功能。

Objectives：To study the effects of hyperbaric oxygen （HBO） on blood serum neuron specific enolase （NSE） and endothelin（ET） among patients with severe contusion and laceration of brain. Methods ：The patients with severe contusion and laceration of brain were randomized into hyperbaric treatment group （n=36）d control group（n=33）. Both group received the same western medicines. In addition ,the treatment group received hyperbaric oxygenation. The efficacy and levels of NST and ET were compared before and after treatment between the two groups. Results ：The total effective rates of treatment group and control group were 97.2% and 72.7% respectively. The levels of NSE and ET in the treatment group were better than those of the control group. There was statistic difference（P〈0.01）. Conclusion： HBO can protect nerve cells through supplying more oxygen,adjusting the vascular contraction and reducing cerebral edema,and improve nerve functions by decreasing NSE and ET levels.