MMP-9、E-cadherin基因蛋白在卵巢浆液性肿瘤中的表达及临床意义

The Expressions of MMP-9 and E-cadherin in Ovarian Serous Tumors and Their Clinical Significance

目的:探讨MM P-9和E-cadherin的表达与卵巢浆液性肿瘤侵袭和转移的关系。方法:应用流式细胞免疫法定量检测MM P-9和E-cadherin在45例卵巢浆液性肿瘤中的表达。结果:MM P-9在卵巢浆液性癌中的表达明显高于卵巢浆液性瘤(P<0.05),而E-cadherin在卵巢浆液性癌中的表达明显低于卵巢浆液性瘤(P<0.05)。MM P-9和E-cadherin均与卵巢浆液性癌组织分级和临床分期密切相关(P<0.05)。且二者在卵巢浆液性癌中的表达密切相关(P<0.05)。结论:MM P-9的高表达和E-cadherin的低表达导致了卵巢浆液性癌的侵袭和转移,二者的表达有相关性。提示MM P-9和E-cadherin可作为诊断和判断预后的指标。

Objective：Aim To probe into the relationship between MMP-9,E-cadherin expression and invasion, mestastasis of ovarian serous tumors. Methods ：The expressions of MMP 9 and E-cadherin Gene Protein in 45 cases with ovarian serous tumors were detected quantitatively by Flow Cytometry （FCM）. Results：Expression of MMP-9 protein found in ovarian serous carcinomas is significantly more than that in ovarian serous cystadenomas（P〈0.05）but expression of E-cadherin protein＇s is significantly less than that in ovarian serous cystadenomas（P〈0.05）. It can be stated that expression of MMP 9 and E-eadherin were correlated with histological grade and clinical stage （P〈0.05）. In 23 cases of ovarian serous carcinomas,the FI of MMP-9 protein was significantly correlated inversely with that of E-cadherin（r=0.89,P=0.02〈0.05）. Conclusion：The high level of MMP-9 and the low level of E eadherin may be linked with ovarian serous tumor invasion and mestastasis,the expression of MMP 9 protein was significantly correlated inversely with that of E-cadherin. The expressions of MMP 9 and E-cadherin may be a indication of invasion and metastasis and a strong predictor of poor survival.