纳络酮治疗眩晕症的临床探讨

The Discussion on The Treatment of Naloxon to Dizziness

目的 探讨纳络酮治疗眩晕症的疗效及起效、缓解时间。方法将118例眩晕症病人随机分为3组：对照组39例，小剂量纳络酮组39例．大剂量纳络酮组40例。观察患者症状缓解情况及药物起效、缓解时间。结果大、小剂量纳络酮组缓解率（72．50％、61．54％）、总有效率（95．00％、92．31％）均高于对照组（缓解率41．03％、总有效率69．23％），其中总有效率两组较对照组均有显著差异（P〈0．05），而大剂量纳络酮组较小剂量纳络酮组又有显著差异（P〈0．05）。在起效时间、缓解时间方面，大剂量纳络酮组（1．72±1．70天、1．79±1．31天）少于对照组（2．27±1．91天、3．59±1．69天）、小剂量纳络酮组（2．00±1．90天、3．31±1．79天），且均有显著差异（P〈0．05）。结论纳络酮治疗眩晕症疗效好，而且大剂量纳络酮疗效更好，起效快。

Objective To discuss the efficacy, onset time, and remission time ofnaloxon in treatment of dizziness. Methods 118 patients presented with vertigo were divided into 3 groups randomly. 39 patients were assigned to control group in treatment, 39 patients to the group used small dose naloxon, and 40 patients to the group used large dose naloxon. The release of symptoms and the time of drug effection were observed. Results The remission rate of the group used large dose naloxon in treatment was 72.5%, totally effective rate was 95.00%. And the rate of the group used small dose was 61.54%, totally effective rate was 92.31%.Thhe remission rate and totally effective rate were all higher than those in the control group （41.03%, 69.23%）. The totally effective rate of the groups used naloxon had significantly differency （P〈0.05）. The group used large dose naloxon and that used some one had significantly differency （P〈0.05）, too. About the drug onset and remission time, the large dose naloxon group （1.72±1.70, 1.79 ±1.31 ） was significantly faster than that in the control group （2.27±1.91, 3.59 ±1.69） and in the small dose naloxon group （2.00 ±1.90, 3.31 ±1.79） （P〈0.05）. Conclusion The curative effect ofnaloxon in the treatment of dizziness is significant, and the large-dose naloxon effects faster.