纳洛酮在急性重型颅脑损伤中的应用观察

Clinical Observation of Naloxone in Acute Severe Brain Injury

目的观察早期大剂量纳洛酮治疗重型颅脑损伤中的应用效果。方法选择脑外伤后格拉斯哥(GCS)评分3～8分患者59例,随机分为纳洛组34例与对照组25例。对照组给予脱水剂,糖皮质激素,抗菌药物及营养脑细胞药+脑复康常规治疗;纳洛酮组在对照组治疗基础上加用纳洛酮10 d,观察两组治疗后GCS评分,呼吸循环指标及觉醒时间等变化。结果纳洛酮组治疗后,意识觉醒时间缩短,呼吸循环衰竭发生率低。结论纳洛酮在解除颅脑损伤中由内源性阿片肽引起的中枢及外周循环抑制有显著作用。

Objective To observe the early high-dose naloxone in the treatment of severe traumatic brain injury results, Methods 59 cases of patients with Glasgow score 3 - 8 points after traumatic brain injury, were randomly divided into naloxone group （34 cases） and control group （25 cases）. The patients in the control group were given dehydrating agent, glucocorticoid, anti-bacterial drugs and nutritional brain cell medicine ＋ conventional brain rehabilitation therapy; the patients in naloxone group were treated with naloxone 10 d, based on the treatment of control group. Two groups were observed in GCS score, respiratory cycle time targets and changes in arousal after treatment. Results After naloxone treatment, the awakening time was shortened and the incidence of respiratory and circulatory failure was lowered. Conclusion Naloxone has a significant role in relieving the central and peripheral circulation inhibition caused by endogenous opioid peptides in traumatic brain injury.