绝经后2型糖尿病患者身体成分与骨密度相关性分析

Correlation analysis between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

目的：探讨绝经后糖尿病（DM）患者身体成分与骨密度（BMD）的关系。方法：采用双能x线BMD检测仪对48例绝经后2型DM患者（DM组）和62例健康体检的绝经后非DM者（非DM组）进行腰椎（L1～L4）正位、左髋和全身BMD检测和身体成分检测，分析比较两组检测结果。结果：（1）两组问股骨、腰椎和全身BMD以及全身、躯干和左大腿组织成分均无显著差异。（2）在DM组，全身脂肪质量和肌肉质量、躯干脂肪质量均分别与腰椎、全身BMD明显正相关；全身肌肉质量、躯干和大腿的脂肪质量和肌肉质量均分别与股骨颈、全身BMD明显正相关。（3）在非DM组，全身脂肪和肌肉质量、躯干脂肪质量均分别与腰椎、股骨（Wards三角除外）和全身BMD呈显著正相关（P〈0．01—0．05）；躯干肌肉质量仅与股骨大粗隆BMD呈正相关（P〈0．05）。结论：绝经后DM患者身体成分与BMD存在一定相关性，与绝经后非DM者相比有较多不同，其差异可能与糖尿病引起的代谢异常有关。

Objective ：To study the relationship between body composition and bone mineral density （BMD） in postmenopansal women with type 2 diabetes mellitus （DM）. Methods ：62 postmenopausal women without DM （ NDM group） and 48 postmenopausal women with DM（ DM group） were scanned by dual - energy X - ray absorptiometry （DEXA） for examination of L1 -L4 normotopia,left hip,whole body BMD and body composition . The results were analyzed and compared between the two groups finally. Results： （ 1 ） The BMD of left femurs, lumbar spine （ L1 - L4 ） and whole body as well as body composite of whole body, trunk and left leg had no significant differences between the two groups. （ 2 ） In DM group,fat tissue mass （FTM） of whole body,lean tissues mass（LTM） of whole body and FTM of trunk were positively correlated with BMD of the lumbar spine and BMD of whole body,respectively. LTM of whole body,FTM and LTM of trunk were significantly positive correlated with BMD of left femur and whole body, respectively. （3） In NDM group, FTM of whole body, LTM of whole body and FTM of trunk were positively correlated with BMD of whole body,lumbar spine and whole femur except Ward＇s triangular area（ P 〈 0. 01 -0. 05 ） respectively, but LTM of trunk was only positively correlated with BMD of troch. Conclusion： Body composition and BMD in postmenopansal women with DM are of certain correlations that are different from those without DM. These differences may be related to metabolic disorders induced by DM.