T-2毒素对雄性小鼠精液质量的影响

Effects of T-2 toxin on semen quality in male mice

目的:探讨T-2毒素对雄性小鼠精液品质的影响。方法:每天腹腔注射T-2毒素,浓度依次分别为0、5、10和15mg/kg,连续7d,然后检测精液品质的变化情况。结果:与对照组相比,不同染毒剂量组精子畸形率均显著增加,而顶体完整率均显著降低,但只有10和15mg/kg两个高染毒剂量组活精子比率显著降低。结论:T-2对雄性小鼠精液品质有明显毒性作用。

Objective： To investigate the effects of T-2 toxin on semen quality in male mice. Methods： Adult male mice were exposed to intraperitoneal （i. p. ） injection of T-2 toxin at 0, 5, 10, and 15 mg/ kg daily for 7 days. Semen quality was assessed. Results： compared with coutrol group, the number of abnormal spermatozoa increased significantly, while, a significant decrease in spermatozoa with integrated acrosome was observed in male mice exposed to T-2 toxin at all dosage levels, but the amount of live spermatozoa decreased significantly in male mice treated with 10 and 15 mg/kg T-2 toxin. Conclusion： T-2 toxin has toxic effects on semen quality of adult male mice.