2Dennler S, Huet S, Gauthier JM. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene 1999; 18: 1643-8.
3Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, et al. Targeted disruption of SMAD3 results in impaired mucosol immunity and diminished T cell responsiveness to TGF-beta.EMBO J 1999; 18: 1280-91.
4Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci USA 1998; 95: 9378-83.
5Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL,Weinstein M, et al. Functional chrarcterization of transforming growth factorβ signaling in Smad2 and Smad3-deficient fibroblasts.J Biol Chem 2001; 276:19 945-53.
6Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci USA 1997; 94:10669-74.
7Zhao J, Shi W, Wang YL, Chen H, Bringas P Jr, Datto MB, et al.Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2002; 282:L585-93.
8Stegemann H, Stalder K. Determination of hydroxyproline. Clin Chim Acta 1967; 18: 267-73.
9Ueno H, Sakamoto T, Nakamura T, Qi Z, Astuchi N, Takeshita A, et al. A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis in rats. Hum Gene Ther 2000; 11: 33-42.
10Giri SN, Hyde DM, Hollinger MA. Effect of transforming growth factor-β on a bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-66.
7Tang M L, Wilson J W, Stewart A G, et al. Airway remodeling in asthma: current understanding and implications for future therapies[J]. Pharmacol Ther, 2006, 112 (2): 474.
8Kenyon N J, Ward R W, McGrew G, et al. TGF-beta 1 causes airway fibrosis and increased collagen 1 and m mRNA in mice[J]. Thorax, 2003, 58 (9): 772.
9Schuster N, Krieglstein K. Mechanisms of TGF-beta-mediated apoptosis[J]. Cell TissueRes, 2002, 307 (1): 1.
10Schmidt Weber C B, Blaser K. Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation [J]. Curr Opin Immunol, 2004, 16 (6): 709.
5Jun-Fang Zhao, Cheng-Hai Liu, Yi-Yang Hu, Lie-Ming Xu, Ping Liu and Cheng Liu Shanghai, China Institute of Liver Diseases, Shanghai University of Tra- ditional Chinese Medicine, Shanghai 200023 , China.Effect of salvianolic acid B on Smad3 expression in hepatic stellate cells[J].Hepatobiliary & Pancreatic Diseases International,2004,3(1):102-105. 被引量:17