我院252例药品不良反应报告分析

ADR Case Reports in Our Hospital:Analysis of 252 Cases

目的:了解我院药品不良反应(ADR)发生的一般规律与特点。方法:收集我院2007～2008年通过网络系统向北京市ADR监测中心上报的ADR报告252份,按患者性别、年龄、给药途径、药品种类、ADR累及器官或系统及临床表现、严重ADR、ADR发生率排序居前10位的药品等方面进行统计、分析。结果:252例ADR报告中涉及的药品共14类101种,其中抗微生物药引发的ADR最多(占49.60%);静脉滴注是引发ADR的主要给药途径(占76.19%);皮肤及其附件损害最常见(占47.67%);严重ADR20例(占7.94%);引发ADR最多的药品是头孢哌酮钠/舒巴坦钠,有26例。结论:临床应重视ADR的报告和监测工作,以减少或避免ADR的发生,促进临床合理用药。

OBJECTIVE： To study the regularity and characteristics of adverse drug reactions （ADR） occurred in our hospital. METHODS： A total of 252 ADR cases submitted to Beijing ADR Monitoring Center by our hospital via network system from 2007 to 2008 were analyzed statistically in respect of patients＇ age and sex, routes of administration, drug care gories, ADR -involved organs or systems and clinical manifestations, serious ADR, and top 10 drugs in terms of number of ADR cases,etc. RESULTS： Of the total 252 ADR cases, the number of drugs involved totaled 14 categories（101 kinds）. Antimicrobial drugs took the lead （49.60%） in terms of the incidence of ADR. Intravenous route was the chief ADR- inducing route, accounting for 76.19%. Lesions of skin and its appendants were the common ADR types, accounting for 47.67%. 20 cases（7.94% ） were severe AI）R cases. The number of ADR cases induced by Cefoperazone Sodium/Sulbaetam Sodium occupied the first place, which totaled 26 cases. CONCLUSION： Importance should be attached to the reporting and monitoring of ADR to lessen or avoid the occurrence of ADR and promote clinical rational use of drugs.