基于Excel函数设计茶碱口服多剂量个体化给药方案

Design of Individualized Dosage Regimen of Multiple Oral Dosing Theophtlline Based on Excel Function

目的:建立一种简便的茶碱口服多剂量个体化给药方案。方法:根据药动学参数,基于Excel函数,以茶碱为例设计单室模型血管外多剂量给药方案。结果:输入患者的生理和病理特征、茶碱每次给药剂量、间隔周期、吸收速率常数、药物清除率、吸收分数、表观分布容积,可计算出任意一次给药后t时刻的血药浓度、达峰时间、最大稳态血药浓度、最低稳态血药浓度、蓄积系数、达坪分数、坪幅,以及小儿和老人给药剂量,可绘制出血药浓度-时间曲线。结论:所采用方法可设计茶碱个体化给药方案,且简单、可靠、直观。

OBJECTIVE： To establish a simple individualized dosage regimen of multiple oral dosing of Theophyllin. METHODS： Based on pharmacokinetic parameters, Excel function was used to design the dosage regimen of multiple oral dosing extravascular administration of one compartment model with Theophylline as an example. RESULTS： The following parameters such as plasma drug concentration at any time （t） since administration of Theophylline, peak time, maximum steady plasmadrug concentration, minimum steady plasmadrug concentration, accumulation coefficient, fluctuation percentage, fluctuation amplitude, and dosage for children and the old could be obtained and the concentration- time curves were able to be drawn from the input data including physical and pathological parameters, dosage （X0） of Theophylline, interval τ, absorption rate constant （Ka）, drug clearance rate （CL）, absorption fraction （F） and apparent volume of distribution （Vd） . CONCLUSION： The method adopted in our study is simple, reliable and intuitive, and it is applicable for the design of the individualized dosage regimen of Theophyllin.