摘要
目的:观察不同剂量神经节苷脂(GM1)对急性脑梗死患者神经功能恢复的治疗效果。方法:120例急性脑梗死患者随机分为大剂量GM1组(n=40)、小剂量GM1组(n=40)和安慰剂组(n=40)。在治疗前1d、治疗后14d时分别对患者神经功能评价。结果:治疗后,各组的NDS评分下降、日常生活活动能力(Barthelindex,BI)评分提高;与安慰剂组相比,GM治疗组患者神经功能恢复水平明显提高(P<0.05);GM治疗组组间比较,大剂量GM1组治疗效果好于小剂量GM1组(P<0.05)。结论:GM1能够促进急性脑梗死损伤后神经功能的恢复,疗效呈剂量依赖性。
Objective ：To observe the effects of different dosage of Gm1 in treating acute cerebral infarction. Methods ：One hundred and twenty cases were randomly divided in three groups ：the first group with high dosage of GM1 ,the second with low dose of GM1 ,the third with placebo. The neurological impairment score and curative effect were evaluated at the day before treatment and the 14th day after treatment. Results ：There were significant differences in neurological impairment score in the three groups. The NDS grades reduced and the grades of BI rised significantly. The treatment effect of GM1 was more obvious than the placebo therapy. In addition,the treatment effect of high dosage of GM1 was more significant than the low dose GM1 group. Conclusion ：GM1 improves the recovery of neurological function of the patients. The treatment effect of high dose GM1 （100 mg/d） is better than the low dose GM1 （40 mg/d）, the medical effects rely on the dosage.
出处
《医药世界》
2009年第9期487-489,共3页
Medicine World
