肿瘤坏死因子-α及其受体与炎症性骨破坏

Research progress of tumor necrosis factor-α and its receptor in bone resorption of inflammatory diseases

肿瘤坏死因子-α涉及诸多生理病理过程,尤其是在炎症性骨破坏方面有着极其重要的作用。肿瘤坏死因子受体的生物学性能与病理性骨改建具有明显的相关性,在颌骨炎症性破坏中同样起着重要的作用。下面就肿瘤坏死因子-α及其受体的生物学性能以及肿瘤坏死因子-α及其受体与骨改建和颌骨炎症性破坏的研究进展作一综述。

Tumor necrosis factor（TNF）-α is involved in many physiological and pathologic processes. It has extremely important effect on bone resorption of inflammatory diseases. The biological ability of tumor necrosis factor receptor has evident correlation with pathologica bone remodeling and it has a significant role in bone resorption of inflammatory disease with jaws. This paper discussed the biological characters of TNF-α and its receptors that affect bone remodeling and bone resorption of inflammatory diseases with jaws.