圣·约翰草提取物对伴有抑郁症的2型糖尿病合并高血压老年患者的疗效

Effects of ST. John＇s wort on depressive disorder in elderly patients with hypertension and diabetes

目的探讨抗抑郁植物药圣·约翰草提取物对伴有抑郁症的2型糖尿病合并高血压老年患者的临床疗效。方法将106例伴有抑郁症的2型糖尿病合并高血压的老年患者随机分为药物治疗组（30例），心理治疗组（24例），物理治疗组（28例）和安慰剂组（26例），均治疗12周。以汉密尔顿抑郁量表（HAMD）减分率评定疗效，监测患者血压水平及糖化血红蛋白值（Hb）A1c。结果（1）各组HAMD减分率分别为80％、54．2％、50％和37％，差异有统计学意义（P〈0．05）。药物治疗组疗效均优于其他3组（P〈0．05）。（2）治疗12周后，各治疗组收缩压及舒张压均较治疗前下降（P均〈0．05），有效率差异有统计学意义（P均〈0．05）。（3）治疗12周后，各治疗组HbAlc值均较治疗前有所下降（P〈0．05）。结论圣·约翰草提取物能显菩改善2型糖尿病合并高血压老年患者伴发的抑郁症，且有利于患者的血压和血糖控制。

Objective To explore the clinical eurative effect of ST. John＇s wort（SWE） on depressive disorder in elderly patients with hypertension and diabetes. Methods 106 hypertensive patients with diabetes and depressive disorder were randomly assigned to SWE group （ n = 30） , psychotherapy group （ n = 24） , physicotherapy group （ n = 28 ） and placebo group （ n = 26） for 12 weeks＇ treatment. The clinical effect were evaluated separately with reduction percent of HAMD and after the treatment, blood pressure levels and HbAlc were monitored. Results （ 1 ） The reduction percent of HAMD was highest （80%） in SWE group, lower in physicotherapy and psychotherapy group （50% and 54.2% ） ,well lowest in placebo group（37% ） , the difference was significant （ P 〈 0.05 ）. The effect of SWE was better than that of the others （ P 〈 0.05 ）. （ 2 ） The level of blood pressure in SWE was significant lower than that of the others（ P 〈 0.05 ）. （ 3 ） The level of HbA 1 c in SWE group was significant lower than that of the others （ P 〈 0.05 ）. Conclusion SWE can efficiently improve the depressive disorder in elderly patients with hypertension and diabetes, and it is good for controlling blood pressure and HbAl c of the patients.