替米沙坦联合苯磺酸氨氯地平治疗高血压的疗效观察

Clinical Study of Hypertension Treated by Telmisartan with Amlodipine

目的比较联用替米沙坦(诺金平)与苯磺酸氨氯地平(络活喜)及单用苯磺酸氨氯地平对原发性高血压的降压疗效及安全性。方法选取76例原发性高血压患者,随机分为两组,Ⅰ组(n=38)给予替米沙坦联合苯磺酸氨氯地平治疗,Ⅱ组(n=38)单用苯磺酸氨氯地平治疗,均1次/d晨服相应药物,连续观察24周后,测收缩压(SBP)、舒张压(DBP)、心率(HR)、左心室舒张末期室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVDd)、左心室重量指数(LVMI)。用药前和用药后检测血液生化指标。结果治疗24周后,两组SBP、DBP较治疗前明显下降(P<0.05)。IVST、LVPWT、LVDd、LVMI明显低于治疗前(P<0.05),治疗后I组与Ⅱ组比较,SBP、DBP、IVST、LVPWT、LVDd、LVMI也有明显下降(P<0.05)。两组的不良反应率都为9%,差异无统计学意义(P>0.05)。结论替米沙坦联合苯磺酸氨氯地平不仅能控制高血压,而且能够逆转高血压引起的左心室肥厚,疗效、安全性及耐受性均好。

Objective To observe the treatment results of hypertension by Telmisartan with Amlodipinc. Methods 76 hypertension patients were randomly divided into two groups, 38 patients were treated by Telmisartan with Amlodipine, and another 38 patients received Amlodipine, the same time SBP, DBP, HR, IVST, LVPWT, LVDd and LVMI were observed before and after treatment. Results After 24 weeks treatment, SBPand DBP were significantly lower than those before treatment （P 〈0.05 ）. IVST, LVPWT, LVDd and LVMI were also significantly lower than those before treatment（ P 〈 0. 05 ）. Afer 24 weeks treatment, the IVST, LVPWT, LVDd and LVMI of group I were significantly lower than those group H （ P 〈 0. 05 ）. Conclusion Telmisartan with Amlodipine not only can lower hypertention but also can reverse left ventricular hypertrophy. Its is security as well as enduring.