急性脑梗死血清Hcy和hs-CRP检测的临床意义

Clinical Significance of Determ ination of Changes of Serum Hcy and hs-CRP Levels in Patients with Acute Cerebral Infarction

目的探讨了急性脑梗死患者治疗前后血清同型半胱氨酸(Hcy)和超敏C-反应蛋白(hs-CRP)水平的变化及意义。方法应用免疫比浊法和化学发光法对80例急性脑梗死患者进行了血清Hcy和hs-CRP水平检测,并与80名正常健康人作比较。结果在治疗前急性脑梗死患者血清Hcy和hs-CRP水平非常显著地高于正常人组(P<0.01),且与梗死灶面积呈正相关(P<0.05),经治疗后2周则与正常人组比较无统计学意义(P>0.05)。结论检测急性脑梗死患者血清Hcy和hs-CRP水平的变化对判断病情和评价疗效均具有重要的临床价值。

Objective To investigate the changes of serum Hcy and hs-CRP levels after treatment in patientswith acute cerebral infarction. Methods Serum hs-CRP （with immunoturbiditymethod）, and Hcy （with chemiluminescence） levels in 80 patientswith cerebral infarction both before and after treatment aswell as 80 controls. Results Before treatment, serum Hcy and hs-CRPlevelswere significantly higher in the patients than those in controls （P 〈0. 01 ）, Moreover, the levelswere positively correlated withthe size of the infarction （P 〈 0. 05）. After treatment for two weeks, the serum Hcy, hs-CRP levels were not significantly differenffrom those in controls （P 〉 0. 05）. Conclusions Detection of serum Hcy and hs-CRP levelswas helpful for the perdiction of treatment efficacy.