L—盐酸赖氨酸对大白鼠生长发育及肝、肾毒性作用的初步观察

Assessment of the Effect of L-hydrochloro LYSINE on Growth and Development and Its Side-Fffect on Liver and kidney in Rats

本文使用不同剂量的赖氨酸对大鼠分别进行了28日的生长发育喂养实验,90日的毒性喂养实验,结果提示:在谷物类食品中,添加0.5%的赖氨酸对幼年动物生长发育有促进作用。对成年动物作用不明显,且超量的赖氨酸会引起肝肾损伤。肝脏的损伤主要表现在灶性坏死,贮脂细胞增多并伴有胶原纤维形成。肾的损伤主要表现在肾浊肿、近曲小管上皮细胞游离面微绒毛消失,细胞内水肿、线粒体肿胀、内质网扩张,细胞内大残余体的形成。

A 28 days growth and development experiment and a 90 days intoxication experiment with —hydrochloro lysine at various dosage levels on young and adult rats were reported.The results were as follows. There were definitely an accelerating effect on growth and development in young rats when adding 0.5% L-lysine to a cereal diet, but no obviously similar effect in adult rats; moreover, a massive dose of L—lysine could induce hepatic and renal damage. The hepatic lesions were focal necrosis and increase of fat—storing cells with collagen fiber formation. In the kidney there were cloudy swelling, microvilli losing, intracellular edema, mitochondrial swelling, endopl asmic reticulum dilatation and residual body formation in the proximal convoluted tubule epithelium.